| ncRNA name | hsa-miR-630 |
| ncRNA Category | miRNA |
| Disease name | age-related cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | lens epithelium; human lens epithelial cell line HLE-B3 |
| Methods | MTT assay, flow cytometry, Hoechst staining, qRT-PCR, microarray, Western blot, fluorescence in situ hybridization (FISH) |
| Expression pattern | up-regulated |
| Functional description | The level of miR-630 in HLECs elevated drastically at the presence of H2O2 (4.14 fold) and this trend remained the same in the cataractous human lenses.miR-630 may play an important role in the formation of PSC and posterior capsular opacification (PCO) for its influence in EMT. |
| PubMed ID | 29653565 |
| Year | 2018 |
| Title | Identification of H2O2 induced oxidative stress associated microRNAs in HLE-B3 cells and their clinical relevance to the progression of age-related nuclear cataract. |
| Drug-related ncRNA | NO |
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